49ers face uncertainty at quarterback as George Kittle sidelined with hamstring issue

San Francisco 49ers quarterback Brock Purdy sustained injuries to his left shoulder and toe in the Week One victory over the Seattle Seahawks and is a question mark for Sunday’s game against the New Orleans Saints, the team said. Tight end George Kittle left the same game early with a hamstring issue that the organization said could sideline him for up to five weeks.

Purdy suffered the shoulder and toe injuries during the 49ers’ opener and is now in a race to be cleared for the club’s upcoming matchup. The team has not provided a firm timetable for his return and listed his availability for Sunday as uncertain, pending further evaluation and treatment.

Kittle exited the Seattle game early after reporting tightness in his hamstring. The 49ers’ medical staff has described the injury as significant enough that Kittle could miss several games, with the organization estimating a recovery window of up to five weeks. The team has not specified whether Kittle will be placed on injured reserve or provided further diagnostic details.

The injuries come after a Week One win in Seattle that left San Francisco facing immediate personnel concerns at two key positions. Purdy has been the 49ers’ starting quarterback since taking over the role in recent seasons, and Kittle remains one of the team’s primary offensive weapons at tight end. The team’s injury report and roster decisions in the coming days will determine short-term lineup changes.

The 49ers’ medical and coaching staffs will continue to evaluate both players through the week. Head coach and team officials are expected to update the injury report during practice and in their pregame availability leading up to Sunday’s contest at the Caesars Superdome in New Orleans.

If Purdy is unable to play, the 49ers will turn to backup options on the active roster to start against the Saints. The organization has not announced any roster moves or confirmed who would start in his place.

The 49ers opened the regular season with a victory over Seattle, but the two injuries raise questions about depth and offensive continuity early in the schedule. The team will balance short-term game preparation with longer-term recovery plans for both players as it assesses the severity of Purdy’s shoulder and toe injuries and Kittle’s hamstring strain.

Further updates are expected as additional testing results are released and the team provides its official health reports prior to Sunday’s game.