NFL Week 4 Schedule Set to Deliver Major Statements as Teams Vie for Momentum

As the NFL season nears the quarter-mark, Week 4 presents a slate ripe for defining momentum as teams chase early-season distinction and stability.

Buffalo, Indianapolis, Los Angeles, Philadelphia, Tampa Bay and San Francisco opened 3-0, while several programs have yet to secure a victory this season: the New York Jets, Miami Dolphins, Houston Texans, Tennessee Titans, New York Giants and New Orleans Saints remain winless through three weeks. In New York, the Giants are expected to turn to Jaxson Dart for his first career start, a development that adds intrigue to a matchup against a strong opponent in Week 4.

The Week 4 schedule kicks off Thursday night with Seattle visiting Arizona, setting the stage for a weekend slate that mixes rematches, divisional tests and potential playoff contenders asserting themselves as the season approaches its first true turning point. The Sunday lineup includes a London-style early game at 9:30 a.m. ET: Minnesota at Pittsburgh, followed by a full bill of 1 p.m. ET starts that feature a slice of marquee matchups and narrative-driven clashes.

Sunday, Sept. 28, 2025:

Minnesota Vikings @ Pittsburgh Steelers (9:30 a.m. ET) Washington Commanders @ Atlanta Falcons (1 p.m. ET) New Orleans Saints @ Buffalo Bills (1 p.m. ET) Cleveland Browns @ Detroit Lions (1 p.m. ET) Carolina Panthers @ New England Patriots (1 p.m. ET) Los Angeles Chargers @ New York Giants (1 p.m. ET) Philadelphia Eagles @ Tampa Bay Buccaneers (1 p.m. ET) Tennessee Titans @ Houston Texans (1 p.m. ET) Indianapolis Colts @ Los Angeles Rams (4:05 p.m. ET) Jacksonville Jaguars @ San Francisco 49ers (4:05 p.m. ET) Baltimore Ravens @ Kansas City Chiefs (4:25 p.m. ET) Chicago Bears @ Las Vegas Raiders (4:25 p.m. ET) Green Bay Packers @ Dallas Cowboys (8:20 p.m. ET)

Monday, Sept. 29, 2025:

New York Jets @ Miami Dolphins (7:15 p.m. ET) Cincinnati Bengals @ Denver Broncos (8:15 p.m. ET)

Among the marquee games, Week 4 highlights include high-profile matchup pairs across the schedule, such as the Jaguars visiting San Francisco in a test against a 49ers squad that has opened strong, and the Ravens meeting the Chiefs in a potential AFC showcase. The Eagles and Buccaneers meet in a clash of conference contenders, while the Chargers travel to the Giants in what could be a pivotal early-season moment for New York’s revamped quarterback plans. The Packers visiting the Cowboys under the primetime lights adds another heavy-hitting element to the weekend.

The Week 4 slate also gives spotlight to the Saints against the Bills and a Bears-Raiders pairing that could shape early-NFC and AFC narratives, respectively. In another notable cross-country test, the Browns head to Detroit to tangle with a Lions squad that used Week 3 to reinforce its own early-season momentum. The Colts visit the Rams in a late-afternoon window that could become a telling predictor for both teams' offenses and defenses, while the 1 p.m. ET set includes the Titans at Texans, a divisional tilt that could tilt the early standings in the AFC South.

As teams leaf through the early-season ledger, Week 4 serves as a pivotal checkpoint for evaluating quarterback development, depth across rosters and the ability to capitalize on opportunities. With several 3-0 teams entering week four and multiple winless clubs seeking long-awaited victories, the outcomes will influence momentum, confidence and the early conversations around playoff potential.

The shift from the quarter mark to the midseason stretch will unfold over the next several days, and observers will be watching which teams can translate early success into sustained performance, while others seek to turn a corner before the calendar turns to October. The NFL schedule, as always, does not guarantee outcomes, but Week 4 provides a clear lens into which teams are mounting a viable early-season push and which may need to recalibrate quickly to stay in the title conversation.